Understanding the role of dMMR/MSI-H in endometrial cancer

Why is MMR/MSI status important?

How biomarker testing may determine your treatment

Biomarkers are molecules found in the tissues or fluids of your body that show if a condition, process, or disease is normal or abnormal. Knowing your mismatch repair (MMR) or microsatellite instability (MSI) status is important because your endometrial cancer may have biomarkers including dMMR (mismatch repair deficiency) or MSI-H (microsatellite instability-high). Testing for these biomarkers can help your doctor decide if JEMPERLI is right for you.

Knowing your MMR/MSI status is also important because:

  • Up to 30% of people with endometrial cancer have dMMR or MSI-H tumors
  • If you have endometrial cancer with the dMMR or MSI-H biomarker, you might benefit from a treatment known as immunotherapy
  • dMMR/MSI-H status may be associated with Lynch syndrome, an inherited condition that increases the risk of endometrial cancer

What do the experts say?

National guidelines recommend MMR/MSI testing if you have endometrial cancer. Consider asking your doctor to test for dMMR/MSI-H.

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