Understanding the role of dMMR in endometrial cancer

Why is MMR status important?

How biomarker testing may determine your treatment

Biomarkers are molecules found in the tissues or fluids of your body that show if a condition, process, or disease is normal or abnormal. Knowing your mismatch repair (MMR) status is important because your endometrial cancer may have biomarkers including dMMR (mismatch repair deficiency). Testing for this biomarker can help your doctor decide if JEMPERLI is right for you.

Knowing your MMR status is also important because:

  • Up to 30% of people with endometrial cancer have dMMR tumors
  • If you have endometrial cancer with the dMMR biomarker, you might benefit from a treatment known as immunotherapy
  • dMMR status may be associated with Lynch syndrome, an inherited condition that increases the risk of endometrial cancer

What do the experts say?

National guidelines recommend MMR testing if you have endometrial cancer. Consider asking your doctor to test for dMMR.

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