You may experience side effects from JEMPERLI

  • Potential Side Effects
  • Side Effects Timing
  • Tips for Potential Side Effects
  • Related FAQs

JEMPERLI is a medicine that may treat certain cancers by working with your immune system. JEMPERLI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

Side effects associated with JEMPERLI

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

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  • Lung problems.
    • cough
    • shortness of breath
    • chest pain
  • Intestinal problems.
    • diarrhea or more bowel movements than usual
    • stools that are black, tarry, sticky, or have blood or mucus
    • severe stomach-area (abdomen) pain or tenderness
  • Liver problems.
    • yellowing of your skin or the whites of your eyes
    • severe nausea or vomiting
    • pain on the right side of your stomach-area (abdomen)
    • dark urine (tea colored)
    • bleeding or bruising more easily than usual
  • Hormone gland problems.
    • headaches that will not go away or unusual headaches
    • eye sensitivity to light
    • eye problems
    • rapid heartbeat
    • increased sweating
    • extreme tiredness
    • weight gain or weight loss
    • feeling more hungry or thirsty than usual
    • urinating more often than usual
    • hair loss
    • feeling cold
    • constipation
    • your voice gets deeper
    • dizziness or fainting
    • changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness
  • Kidney problems.
    • change in the amount or color of your urine
    • blood in your urine
    • swelling in your ankles
    • loss of appetite
  • Skin problems.
    • rash
    • itching
    • skin blistering or peeling
    • swollen lymph nodes
    • painful sores or ulcers in your mouth or in your nose, throat, or genital area
    • fever or flu-like symptoms
  • Problems in other organs and tissues.

    These are not all of the signs and symptoms of immune system problems that can happen with JEMPERLI. Call or see your healthcare provider right away for any new or worse signs or symptoms.

    • chest pain, irregular heartbeat, shortness of breath, swelling of ankles
    • confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
    • double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
    • persistent or severe muscle pain or weakness, muscle cramps
    • low red blood cells, bruising 
  • Infusion reactions that can sometimes be severe or life-threatening.
    • chills or shaking
    • itching or rash
    • flushing
    • shortness of breath or wheezing
    • dizziness
    • feel like passing out
    • fever
    • back or neck pain
  • Rejection of a transplanted organ.
    • Your healthcare provider should tell you what signs and symptoms you should report and monitor you, depending on the type of organ transplant that you have had.
  • Complications, including graft-versus-host-disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic).
    • These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with JEMPERLI. Your healthcare provider will monitor you for these complications.

In study participants receiving JEMPERLI + carboplatin and paclitaxel (CP), 19% stopped taking JEMPERLI completely and 37% had their treatment interrupted due to side effects.

The most common side effects of JEMPERLI + CP include nerve problems in your arms, hands, legs, and feet; tiredness; nausea; hair loss; joint pain; rash; constipation; diarrhea; stomach-area (abdomen) pain; shortness of breath; decreased appetite; urinary tract infections; vomiting.

Getting medical treatment right away may help keep these problems from becoming more serious.

Your healthcare provider will check you for these problems during treatment with JEMPERLI and may treat you with corticosteroid or hormone replacement medicines. If you have severe side effects, your healthcare provider may also need to delay or completely stop treatment with JEMPERLI.

When you may experience common side effects with JEMPERLI + CP

The 4 most common side effects with JEMPERLI + CP were hair loss, tiredness, nausea, and nerve problems in the arms, hands, legs, and feet. The graph below shows the median start time and duration of these side effects.

  • In the clinical trial, the median time these side effects began was within the first 5 weeks of treatment
  • These are not the only side effects that may happen and these or other side effects may happen at any time during treatment or even after your treatment has ended

Start time and duration of the 4 most common side effects with JEMPERLI + CP and placebo + CP

Median start time and duration of the four most common side effects with JEMPERLI + CP and placebo + CP

Median is the middle value of a set of measurements.

Duration is the length of time the event lasted.

Range is the shortest time and the longest time that people experienced the event.

How to read and understand this graph

  • The black dot shows the median time when patients in the trial started having a side effect. The time, in weeks, is written inside each bar
  • The multicolored bar shows the median amount of time (in weeks) that patients had experienced the first event of each side effect with JEMPERLI + CP. The gray bar shows the median amount of time (in weeks) that patients had experienced the first event of each side effect with the placebo + CP
  • At the end of each bar, the first number is the median duration in weeks, with the number in parentheses indicating the full range patients experienced this event, with the first number being the shortest duration and second number being the longest duration

Watch out for and talk to your doctor

about any and all side effects that you experience. They may be a sign of other more severe or life-threatening problems.

Tips for potential side effects

Everyone’s treatment experience is different. You may experience side effects when you are given JEMPERLI + CP.

Please see below for more information on tips your healthcare team may suggest for certain side effects. These are not all of the possible side effects of JEMPERLI + CP. Always let your healthcare provider know of any side effects you may experience and follow their guidance.

Tips for potential side effects associated with JEMPERLI + CP

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  • Nerve problems in your arms, hands, legs, and feet

    Talk to your care team about their recommendations for dealing with nerve problems, which may include:

    • Checking hands and feet regularly for any injuries, cuts, or sores
    • Avoiding or limiting alcohol
    • Performing gentle stretching and balancing exercises
    • Protecting your hands and feet from extreme temperatures, like wearing shoes and warm clothes when it’s cold and protecting your hands from heat while cooking
    • Preventing falls by moving rugs out of your path and putting rails on the walls and in the bathroom
    • Getting up slowly after sitting or lying down, especially if you feel dizzy
    • Taking a medicine for pain, which may include a prescription or over-the-counter patch or cream, and should be taken as instructed
  • Tiredness

    Talk to your care team about their recommendations for dealing with tiredness, which may include:

    • Planning your day to prioritize things that are most important and spreading activities throughout the day
    • Taking rest breaks or short naps rather than one long nap
    • Planning an appropriate exercise program for you
    • Aiming for 7 to 8 hours of sleep each night
    • Avoiding things that interrupt sleep, such as caffeine and evening exercise
  • Nausea

    Talk to your care team about their recommendations for dealing with nausea, which may include:

    • Trying to avoid skipping meals or snacks—an empty stomach may make nausea worse
    • Sipping liquids slowly throughout the day
    • Keeping dry toast, crackers, and other bland foods on hand
    • Avoiding fatty, fried, spicy, or very sweet foods
    • Taking a medicine for nausea, which can be either prescription or over-the-counter and should be taken as instructed
    • Trying aromatherapy, such as peppermint
  • Hair loss

    Talk to your care team about their recommendations for dealing with hair loss, which may include:

    • Determining likelihood of hair loss and when it might begin
    • Acknowledging that it’s natural to feel upset about hair loss, and that some people choose to cut their hair short or shave their head before hair loss starts
    • Trying wigs, scarves, and hats to see which option you prefer if it feels right for you
  • Joint pain

    Talk to your care team about their recommendations for dealing with joint pain, which may include:

    • Applying a cold compress, an ice pack, or a package of frozen vegetables to the painful area for 15 to 20 minutes a few times each day
    • Visiting a physical therapist who can teach you gentle stretching exercises to ease muscle tension
    • Applying a heating pad, soaking in a warm tub, or taking a warm shower to relax muscles and increase blood flow
    • Taking a medicine for pain, which can be either prescription or over-the-counter and should be taken as instructed
  • Rash

    Talk to your care team about their recommendations for dealing with rash, which may include:

    • Using mild lotions and moisturizers
    • Using mild soap and a soft cloth to gently clean the area
    • Staying out of the sun as much as you can
    • Protecting the area from heat and cold
    • Taking a medicine for rash, which can be either prescription or over-the-counter and should be taken as instructed
  • Constipation

    Talk to your care team about their recommendations for dealing with constipation, which may include:

    • Trying to eat more high-fiber foods like fresh fruits and vegetables, oats, whole-grain bread, and brown rice
    • Staying as active as you can with an appropriate exercise plan for you
    • Drinking plenty of fluids, but be sure to ask your care team how much is safe for you to drink
    • Taking a medicine for constipation, which can be either prescription or over-the-counter and should be taken as instructed
  • Diarrhea

    Talk to your care team about their recommendations for dealing with diarrhea, which may include:

    • Avoiding fried foods and high-fiber foods like beans and whole grains
    • Reducing the use of alcohol or tobacco
    • Taking a medicine for diarrhea, which can be either prescription or over-the-counter and should be taken as instructed
  • Decreased appetite

    Talk to your care team about their recommendations for dealing with decreased appetite, which may include:

    • Trying to eat small amounts more frequently, and taking advantage of times when you’re hungry to eat more, if you feel full after eating a small amount
    • Keeping snacks handy, so that you can eat when you’re feeling up to it
    • Asking a dietitian about shakes and instant drink mixes
    • Scheduling your mealtimes, instead of relying on eating only when you feel hungry
  • Urinary tract infection (UTI)

    Talk to your care team about their recommendations for dealing with UTIs, which may include:

    • Drinking plenty of liquids, so that urine is light yellow or clear, but be sure to ask your care team how much is safe for you to drink
    • Preventing UTIs by going to the bathroom often, wearing cotton underwear and loose-fitting pants, and taking showers instead of baths
    • Avoiding things that may make bladder problems worse, such as drinks with caffeine, alcohol, spicy foods, and tobacco products
    • Taking a medication as recommended by your care team
  • Vomiting

    Talk to your care team about their recommendations for dealing with vomiting, which may include:

    • Avoiding foods with strong or unpleasant smells
    • Sipping liquids slowly until you feel good enough to drink more
    • Talking with your care team about how to stay hydrated and how much is safe for you to drink
.

What is JEMPERLI?

JEMPERLI is an immunotherapy. This means it is designed to work with the body’s immune system to help fight cancer.

Learn How It Works

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JEMPERLI study results

Want to learn how JEMPERLI may help?

See Study Results

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Resources for you

Knowledge is power. That's why we're committed to providing you with educational resources to help you stay informed along your treatment journey.

Go to Resources

Related FAQs

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  • How is JEMPERLI given?

    JEMPERLI is given through an intravenous (IV) infusion. It takes approximately 30 minutes.

  • What is immunotherapy?

    Immunotherapy (IH-myoo-noh-THAYR-uh-pee) is a treatment that is designed to work with the body’s immune system to attack cancer cells. JEMPERLI is an immunotherapy that may help your body’s immune system fight cancer.

  • How has JEMPERLI been studied?

    Researchers have conducted clinical trials to study the effectiveness, risks, and side effects associated with JEMPERLI. Trials are ongoing.

  • How many people participated in the clinical trial of JEMPERLI in combination with carboplatin and paclitaxel?

    There were 494 patients included in the clinical trial that studied the effectiveness of JEMPERLI in combination with the chemotherapy medicines, carboplatin and paclitaxel, compared to carboplatin and paclitaxel alone. They had endometrial cancer that was newly-diagnosed and had spread outside the uterus (advanced) or had returned.

    The clinical trial also studied the risks and side effects of JEMPERLI in combination with the chemotherapy medicines, carboplatin and paclitaxel, in 241 people with newly-diagnosed advanced or returned endometrial cancer.

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